Why liver congestion turns dangerous: A newly mapped pathway to fibrosis and cancer

The long-term stasis of blood in the liver, known as chronic liver congestion, can lead to a range of diseases, some of which ...
The Manila Times

Illumina partners go beyond the genome, driving cancer breakthroughs using spatial transcriptomics, epigenomics, and proteomics

The human lymphatic system is notoriously difficult to map due to its size and variability among individuals. Spatial ...

Think You’re Too Young for Colon Cancer? Think Again.

I try not to think of what would have happened if they had found this at the beginning,” says Runkel. “I find that if I just ...
Tech Xplore

'Learn-to-Steer' method improves AI's ability to understand spatial instructions

Researchers from the Department of Computer Science at Bar-Ilan University and from NVIDIA's AI research center in Israel ...

Machine-learned biomarker identifies those at high risk for liver cancer

Researchers led by Xian-Yang Qin at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have developed a score that predicts the risk of liver cancer. Published in the journal Proceedings ...
Frontiers

DWGCN: distance-weighted graph convolutional network for robust spatial domain identification in spatial transcriptomics

Graph Convolutional Networks (GCNs) are widely applied for spatial domain identification in spatial transcriptomics (ST), where node representations are learned by aggregating information from ...
Frontiers

Integrated single-cell and spatial transcriptomics reveal the differentiation drivers of gastric epithelial lineage progression

Gastric cancer (GC) develops through a sequence from chronic gastritis to intestinal metaplasia (IM) and carcinoma, with Helicobacter pylori (HP) as a key driver; however, the molecular mediators ...
IEEE

Cluster-guided contrastive learning with masked autoencoder for spatial domain identification based on spatial transcriptomics

Abstract: Recent advancements in spatial transcriptomics technology have enabled the capture of gene expression profiles while maintaining spatial information. Accurately identifying spatial ...
IEEE

Adaptive Weighting Contrastive Learning for Spatial Domain Identification in Spatial Transcriptomics

Abstract: The rapid advancement of spatial transcriptomics has enabled the joint analysis of gene expression and spatial location data. This integration opens new avenues for uncovering tissue ...
Cancer Research

American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license. This work is licensed under a Creative Commons Attribution 4.0 International ...