Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

Scientific progress depends on results that can be repeated – yet across disciplines, too many experiments fail that test. From medicine to economics, the replication crisis reveals not just flawed ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

DNA, often called the blueprint of life, is built from four chemical building blocks known as deoxy-nucleoside triphosphates (dNTPs)—dATP, dTTP, dGTP, and dCTP. Cells constantly need these molecules ...

This important theoretical study examines the possibility of encoding genomic information in a collective of short overlapping strands (e.g., the Virtual Circular Genome (VCG) model). The study ...

Unlock the full InfoQ experience by logging in! Stay updated with your favorite authors and topics, engage with content, and download exclusive resources. Cory Benfield discusses the evolution of ...

Amanda Kay Montoya is an Associate Professor at the University of California, Los Angeles. She serves on the Board of Directors for the Center for Open Science. She receives funding from the ...

The Presidential Commission to Make America Healthy Again (MAHA) released a report on children’s health last month, and it uses the word “crisis” no fewer than 40 times within 72 pages. One of these ...

Science is often described as self-correcting, given its basis in empirical testing and because falsehoods put forth can, in principle, be dismantled through further experiments. Yet, when the ...

Accurate genome duplication is essential for all living cells. In Escherichia coli and most other bacteria, a circular chromosome is replicated bidirectionally at high speed. Two replisomes, assembled ...