As for python-igraph when drawing a self-loop, it does not seem to be able to change the orientation of the self-loop by modifying edge.loop.angle like r version. After reading your code, I find that ...

In the last two decades, there has been an explosion of interest in modeling the brain as a network, where nodes correspond variously to brain regions or neurons, and edges correspond to structural or ...

The command "get_adjacency_sparse" does not return a sparse matrix (i.e., csr_matrix) instead it returns an igraph matrix object. However the documentation mentions that a csr_matrix should be ...