Histone deacetylation and other modifications, particularly the methylation of lysine 9 within histone H3 (H3-K9) residues located in the histone tails, cause chromatin condensation and block ...

Modification of histone tails, by acetylation, methylation or phosphorylation, affects the local chromatin structure and the transcriptional regulation of adjacent genes. Pericentric heterochromatin ...

Posttranslational modifications on histone proteins play a role in regulating chromatin structure and gene expression. Now another so-called histone mark can be added to the list: lysine benzoylation.

Schematic diagram illustrating the novel epigenetic pathway. The dual modification on histone variant H3.3 recruits CBX7, which brings the scaffold protein KAP1 to chromatin. KAP1 facilitates H3K9me3 ...

Strands of DNA wrapped around a histone. Credit: Molekuul/Science Source Histones are among the most abundant proteins in the body. They act as spools that help compact DNA so our enormous genomes ...

Histone modification is an epigenetic mechanism that enables fine-tuning of gene expression. Mutation or dysregulation of proteins associated with histone modification (called “writers,” “erasers,” ...

Our group has contributed to the molecular and functional understanding of histone mark and DNA methylation mark readout by writer, reader and eraser proteins, as well as investigated the crosstalk ...

Chromatin is one of the earliest identified targets for cancer therapeutics. Drug development aimed at altering chromatin can be traced to the differentiating agents of the 1970s and their link to DNA ...

Salt stress remains a critical challenge for plant growth, especially in crops like pea (Pisum sativum L.). This study explores the role of histone modifications in regulating pea's response to salt ...

What is the histone code? Different chemical marks, such as acetylation, methylation, or phosphorylation, are made to numerous residues on the N-terminal tails of histone proteins. Some posit that ...