TWILIGHT adopts the progressive alignment algorithm (Fig. 1c) and employs tiling strategies to band alignments (Fig. 1e). Combined with a divide-and-conquer technique (Fig. 1a), a novel heuristic ...

Abstract: Multiple Sequence Alignment (MSA) is a fundamental challenge in bioinformatics, forming the basis for addressing numerous computational biology problems, e.g., protein structure prediction ...

FlexiDot is a cross-platform dotplot suite generating high quality self, pairwise and all-against-all visualizations of transposons and other discrete sequences. To improve dotplot suitability for ...

Abstract: Modern sequence alignment tools rely on seed-based anchoring to efficiently align large-scale sequencing data. Minimizers are widely used for seed extraction but often generate excessive and ...