eLife

A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B

Human MAP1LC3B (LC3B) binds proteins involved in autophagy and other cellular processes using a degenerate four-residue short linear motif known as the LC3-interacting region (LIR). Biochemical and ...

The Edge of Mathematics

Tao: Today there are a lot of very tedious types of mathematics that we don’t like doing, so we look for clever ways to get ...
ABC7

UCI Health launches promising clinical trial using CAR T-cell therapy to treat lupus

LOS ANGELES (KABC) -- For decades, treatments for lupus, which affects 1.5 million Americans, have been few and far between. The condition affects mainly women and can be debilitating. Now, a ...
eLife

Contractile peri-nuclear actomyosin network repositions peripheral and polar chromosomes to promote early kinetochore–microtubule interactions

This important study demonstrates that a peri-nuclear actomyosin network, present in some types of human cells, facilitates kinetochore-spindle attachment of chromosomes in unfavorable locations - ...