Our single-celled ancestor lived in a world without plants, animals or oxygen-rich oceans. Yet, this seemingly simple microorganism took the first steps toward complex life. From this ancestor emerged ...

All complex biological systems—like the DNA, RNA and proteins constantly being copied and built within our cells—are prone to errors. That means as life evolved to be more elaborate, it also had to ...

Scientists have discovered that a protein once thought to simply help load a factor necessary for the copying of DNA, actually plays a key role in ensuring fast and reliable replication—an insight ...

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...

DNA replication is a semi-conservative process in which half of the newly synthesized strands (daughters) are derived from the original strands (mothers). The confirmation of semi-conservative ...

DNA is the blueprint of life, but how much do you know about it?Dr_Microbe DNA serves as the blueprint of life for every species. We already know a good deal about DNA and how genetics works. But here ...

For years, the federal government has been amassing DNA profiles of noncitizens. But recently released Customs and Border Protection (CBP) data reveal that officials knowingly collected the DNA of ...

This valuable paper describes the crystal structure of a complex of the Sld3-Cdc45-binding domain (CBD) with Cdc45, which is essential for the assembly of an active Cdc45-MCM-GINS (CMG) double-hexamer ...

DNA, deoxyribonucleic acid, carrying encoded genetic information at molecular level, is the most significant discovery in the history of genetics. Previous researches on DNA included topics of bases, ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. A comprehensive understanding of the atomic level mechanism governing the binding ...

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Dr Liu is a ...