Scientists have cracked a key mystery behind spider silk’s legendary strength and flexibility. They discovered that tiny molecular interactions act like natural glue, holding silk proteins together as ...

Scientists have identified the molecular interactions that give spider silk its exceptional strength and flexibility, opening the door to new bio-inspired materials for aircraft, protective clothing ...

This valuable work describes a computational and experimental workflow that turns a moderately stable α-helical bundle into a very stable fold. The authors advance our understanding of α-helix ...

This study reports insights into how the caspase Dcp-1, best known for cell death, can also promote tissue growth in Drosophila, extending the authors' earlier work by identifying regulatory factors ...

This figure highlights four main modules: (1) Molecular & Computational Frontiers, represented by AlphaFold3 protein structure prediction (precision diagnostics), GeneCompass federated learning, and ...

A new AI model is opening the black box of the leading artificial intelligence tool for predicting how proteins will interact with small molecules, such as drugs. The model, OpenFold3, which launched ...

Scientists today released a ‘sneak preview’ of a new open-source artificial intelligence (AI) model that predicts 3D structures of proteins, and say it is close to matching the performance of Google ...

A supercomputer has helped to create an artificial intelligence model that deciphers the “language of proteins.” Scientists at the University of Glasgow used the Tursa supercomputer at the UK’s DiRAC ...

Precisely predicting interactions between diverse biomolecules, including small molecules, peptides, and nucleic acids, is fundamental to drug design. We developed SiteAF3, a generalized, ...

Summary: Researchers used AlphaFold3, the latest AI-based protein modeling system, to predict the structures of all 25 known human bitter taste receptors (T2Rs). Compared with AlphaFold2, AF3 ...