Aldehyde dehydrogenase‐2 (ALDH2), a mitochondrial enzyme, detoxifies reactive aldehydes such as 4‐hydroxy‐2‐nonenal (4HNE). A highly prevalent E487K mutation in ALDH2 (ALDH2*2) in East Asian people ...

A new biocatalytic pathway has been engineered that directly converts aldehydes into amides – essential for many drug molecules. The new approach, which uses oxygen from the air and water as the ...

A single type of chemical structure that shows up again and again in modern medicine is the amide bond that links a carbonyl group (C=O) to a nitrogen atom. They're so ubiquitous that 117 of the top ...

Acute myocardial infarction caused by thrombosis is a major cause of mortality. A polymorphism in aldehyde dehydrogenase 2 (Aldh2) rs671 is found in approximately 30% to 50% of East Asians, and it is ...

Chemical structure of imatinib, a precision cancer drug containing an amide bond. Xiaoguang Lei and his team used their engineered enzyme to streamline the synthesis of imatinib, a landmark cancer ...

Aldehyde dehydrogenase 2 (ALDH2) is an important enzyme that detoxifies harmful aldehydes produced in the body. While it is best known for metabolizing acetaldehyde –an aldehyde increased by drinking– ...

Aldehyde dehydrogenase 2 (ALDH2) is an important enzyme that detoxifies harmful aldehydes produced in the body. While it is best known for metabolizing acetaldehyde—an aldehyde increased by ...

They have been used in perfumery for over a hundred years, but are now thrilling new audiences with a modern upgrade. Aldehydes provide a dazzling freshness to fragrance, and when they were first ...

Diisobutylaluminum hydride (DIBAL-H) is an organometallic compound that has found wide use as a reducing agent. The molecule’s nominal structure is shown in the 3-D image: but under ambient conditions ...

Alcohol intolerance is the medical term for an immediate and unpleasant reaction to consuming alcohol. Common symptoms include skin flushing, nasal congestion, and headaches. Alcohol intolerance is an ...