Bringing quantum ideas to the messy world of disordered proteins

Imagine trying to design a key for a lock that is constantly changing its shape. That is the exact challenge we face in ...
eLife

A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B

Human MAP1LC3B (LC3B) binds proteins involved in autophagy and other cellular processes using a degenerate four-residue short linear motif known as the LC3-interacting region (LIR). Biochemical and ...
Communications of the ACM

A Decade of Docker Containers

Docker is a widely used developer tool that first simplifies the assembly of an application stack (docker build), then allows for the rapid distribution of the resulting executabl ...
eLife

TAD boundary architecture and gene activity are uncoupled

A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD and by suppressing interactions between TADs. Here, we directly probe the ...

Lab-in-the-loop framework enables rapid evolution of complex multi-mutant proteins

The search space for protein engineering grows exponentially with complexity. A protein of just 100 amino acids has 20100 ...