ascopubs.org

Bayesian Adaptive Randomization: Full of Promise With a Helping of Caution

Poly(ADP-ribose) Polymerase Inhibitor Combinations in First-Line Metastatic Castration-Resistant Prostate Cancer: Increasing Toxicity With Unclear Benefits In the article that accompanies this ...
EurekAlert!

PCSK9 inhibitors may reduce low back pain risk: a Mendelian randomization study

A Mendelian randomization study reveals PCSK9 inhibitors may reduce low back pain (LBP) risk, while HMGCR and NPC1L1 ...
The New England Journal of Medicine

Community-Based Cluster-Randomized Trial to Reduce Opioid Overdose Deaths

Evidence-based practices for reducing opioid-related overdose deaths include overdose education and naloxone distribution, the use of medications for the treatment of opioid use disorder, and ...
The New England Journal of Medicine

Randomized, Controlled Trial of the FGF21 Analogue Pegozafermin in NASH

Pegozafermin is a long-acting glycopegylated (pegylated with the use of site-specific glycosyltransferases) fibroblast growth factor 21 (FGF21) analogue in development for the treatment of ...
Targeted Oncology

SUCCESSOR-2 Study Shows PFS Benefit With Mezigdomide in Relapsed Myeloma

Mezigdomide (a CELMoD) combined with carfilzomib/dexamethasone met the phase 3 primary endpoint, delivering statistically significant, clinically meaningful PFS improvement versus Kd in ...
ascopubs.org

Gemcitabine and Paclitaxel Versus Gemcitabine Alone After 5-Fluorouracil, Oxaliplatin, and Irinotecan in Metastatic Pancreatic Adenocarcinoma: A Randomized Phase III PRODIGE 65 ...

Radiographic Progression-Free Survival and Clinical Progression-Free Survival as Potential Surrogates for Overall Survival in Men With Metastatic Hormone-Sensitive Prostate Cancer Patients with ...