Polysubstance use disorder is a mental health condition in which someone uses more than one substance at the same time or within a short period of time, despite a pattern of negative effects.

A massive survey recently released by a national drug-testing company strongly suggests we are well into the “fourth wave” of the opioid crisis. The three previous waves were driven by 1) prescription ...

PWH with substance use face increased risks of housing instability, food insecurity, and transportation issues compared to controls. Polysubstance users have higher odds of depression, mania, and ...

Polysubstance use has become a defining feature of the U.S. overdose crisis in the past decade. While not every overdose involves multiple substances, a significant and growing proportion includes ...