Chinese researchers have developed a photocatalytic membrane reactor that dramatically improves the synthesis of imines—a ...

Mechanochemical synthesis harnesses mechanical energy to drive chemical transformations under solvent‐minimised or solvent-free conditions. This approach, frequently executed by ball milling or liquid ...

I am writing to express my displeasure regarding the letter to the editor by Julian Tyson (C&EN, March 14/21, 2022, page 5) about “metal-free” reactions (Feb. 14, 2022, page 20). Specifically, my ...

With artificial intelligence, scientists can design increasingly complex small molecule structures. Automation is critical for transforming these compounds from designs on a screen into actual ...

Process development is key to identifying the optimal parameters used for synthesis, manufacturing, and stability testing. It is also key to generating the data required for the filing processes of ...

Highly reactive organometallic reagents, like organolithiums (molecules with a carbon–lithium bond) are essential reagents in organic synthesis because of their applications from polymer synthesis to ...

This module explores the synthesis of amines with a focus on the reductive amination reaction. Numerous examples from the discovery and commercial manufacturing of pharmaceuticals are included. After ...