The vast majority of experimental work in behavioral and biomedical science involves group comparison—in the simplest case, an experimental and a control group. Average data are compared and the ...

Researchers have identified a molecular brake that limits DNA replication in healthy cells, revealing how cells prevent a long-suspected replication catastrophe and pointing to a potential ...

There has been tremendous progress in the past few years regarding our understanding of DNA replication in eukaryotes, both yeast and mammals. Many important questions in the field are poised to be ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

Stem cells are key for the continual renewal of tissues in our bodies. As such, manipulating stem cells also holds much promise for biomedicine if their regenerative capacity can be harnessed. However ...

To ensure precise duplication of chromosomal DNA, replication origins are 'licensed' for replication during late mitosis and early G1 by loading complexes of the Mcm2–7 proteins. The licensing system ...

Initiator proteins recognize and bind to the replicator and serve to initiate DNA replication. The activities that are provided by initiator proteins range from recognition of the ori and recruitment ...