Pyroptosis is a form of cell death that relies on gasdermins-mediated formation pores in the plasma membrane, which subsequently promotes inflammation by releasing immunogenic cellular contents. The ...

Epstein-Barr virus infection induces the upregulation of glycolysis in intestinal macrophages, which subsequently activates Gasdermin D, NLRP3, interleukin-1β, and interleukin-18 in macrophages within ...

Kangbaida (Sichuan) Biotechnology Co. Ltd. has disclosed pyroptosis and NLRP3 inflammasome inhibitors reported to be useful for the treatment of cancer, type 1 diabetes, gout, inflammatory disorders, ...

Neurogenic bladder is a disease involving inflammation and fibrosis of the bladder. Fibrosis has been linked to the type of programmed cell death known as pyroptosis, which in turn has been linked to ...

Inflammasomes are more active in the morning than the rest of the day. Macrophage activity, which regulates inflammation, is influenced by the biologic clock in the body. A team led by Annie Curtis, ...