A new study has uncovered how an exceptionally scarce protein can orchestrate the assembly of large-scale gene-silencing structures inside cells, and what happens when that process breaks down. The ...

Mount Sinai researchers have discovered that Polycomb complexes, groups of proteins that maintain gene expression patterns, are essential for proper skin development, according to a paper published in ...

A mounting body of evidence is uncovering how the polycomb group (PcG) proteins play a key role in the initiation, development, and progression of cancer in humans. Image Credit: ibreakstock / ...

Single-molecule imaging shows that three CBX2 protein molecules can seed Polycomb condensates that silence genes in stem cells. The discovery reveals how rare proteins organize genome regulation and ...

The dentate gyrus (DG) is the input region of the hippocampus and plays an important role in learning and memory. Although emerging evidence suggests that abnormal expression of the polycomb ...

Polycomb-repressive complexes (PRCs) play key roles in development by repressing a large number of genes involved in various functions. Much, however, remains to be discovered about PRC-silencing ...

Prostate cancer becomes fatal when associated with metastasis. In the October 10 Nature, Sooryanarayana Varambally and colleagues describe a microarray-based analysis of genes whose expression is ...

Most of our genome is often written off as “junk DNA”, meaning it doesn’t encode for genes that get made into proteins. This so-called junk consists of accumulated DNA elements like viral DNA that got ...

This is a preview. Log in through your library . Abstract To equalize X-chromosome dosages between the sexes, the female mammal inactivates one of her two X chromosomes. X-chromosome inactivation (XCI ...

The existence of transgenerational epigenetic inheritance has now been demonstrated among Drosophila fruit flies. By temporarily modifying the function of Polycomb Group (PcG) proteins--which play an ...