How a tryptophan-rich allosteric communication network helps activate a major drug target receptor

A multinational research team led by researchers at Institute of Science Tokyo, RIKEN, and the University of Toronto has ...

Intracellular signaling proteins emerge as a key target in drug development

In a recently published review, a research team led by MedUni Vienna has highlighted a promising new approach to drug discovery. The focus is on the targeted modulation of certain intracellular ...

Scientists track real-time signaling in T cell activation to show how the immune system defends against threats

T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on ...
Medscape

Spiperone Enhances Intracellular Calcium Level and Inhibits the Wnt Signaling Pathway

Background: Wnt signaling affects fundamental development pathways by regulating cell proliferation and differentiation. Aberrant activation of Wnt/ß-catenin signaling promotes the development of ...

INDIGO Biosciences Launches CHRM1 (Cholinergic Receptor, Muscarinic 1) Reporter Assays for Cognitive Drug Discovery

New Assay Expands INDIGO’s GPCR Portfolio and Supports Development of Next-Generation CNS-Related Therapeutics STATE ...
News Medical

Molecular bumpers and glues rewire GPCR signaling for next-generation medicines

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...
Technology Networks

Targeting Intracellular Signaling Proteins for Precision Drug Development

Researchers report a drug discovery strategy using tailor-made cyclic peptides to target β-arrestins, key regulators of ...

Uncovering a key signaling pathway linking liver cancer and fibrosis

New molecular insights into the link between hepatocellular carcinoma and intratumoral fibrosis could lead to better ...