Genome instability can cause numerous diseases. Cells have effective DNA repair mechanisms at their disposal. A research team has now gained new insights into the DNA damage response. Whenever cells ...

Study establishes for the first time that defective DNA repair may be the major driver of several clinical features associated with a subset of patients with 22q11.2 distal deletion syndrome ...

Antisense oligonucleotides (ASOs), used to treat genetic diseases, can affect how cells repair damage to their DNA. This is ...

There is significant crosstalk between DNA damage response (DDR) pathways and innate immune pathways. Both the individual pathways and their interactions are key areas of interest for the development ...

Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes) and is ...

Circulating tumor DNA (ctDNA), small pieces of DNA released from dying tumor cells into the bloodstream, can be easily and non-invasively identified and examined through a simple blood test. This ...

Artios Pharma collected $115 million from an oversubscribed series D that will support its growing ambitions for its pipeline of DNA damage response (DDR)-targeting cancer prospects. The biotech is ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate ...