HRR mutations are commonly of germline origin, with several real world studies suggesting a 23-44% probability of an HRR ...

An expert spoke with CURE® about the importance of information that can be gained from genetic testing for patients with breast cancer. Germline testing, or genetic testing of the DNA that a person ...

From 7% to nearly 9% of patients with advanced cancer were found to harbor a germline variant with targeted therapeutic actionability in the first study of its kind. The study involved 11,974 patients ...

Hereditary breast cancer results from inherited mutations, primarily in BRCA1 and BRCA2, increasing lifetime cancer risk. Additional genes like TP53, PTEN, PALB2, CHEK2, and ATM also contribute to ...

Precision medicine in prostate cancer utilizes genetic testing to identify patients for PARP inhibitor treatment, enhancing personalized care. Genetic testing, including germline and somatic, is ...

A retrospective study was performed to analyze the results of clinical germline genetic testing (March 2020-January 2023) among a cohort of consecutive Emirati patients at risk for hereditary breast ...

Germline genetic testing for BRCA in younger breast cancer patients has become increasingly important. BRCA status can inform a patient's decision to undergo intensive surveillance, bilateral ...

Young breast cancer survivors without a specific genetic mutation have a lower risk of developing second primary breast cancer within 10 years of diagnosis. Young patients that survived breast cancer ...