I regret to say there is no simple or easy answer to this question. Many people use the word ‘depression’ to refer to normal disappointment or sadness, and there can be little doubt that the concept ...

In a recent study published in Nature Medicine, researchers used functional magnetic resonance imaging (fMRI) data on brain circuit function to derive interpretable, personalized brain circuit ...

Depression is characterized by a persistent low mood that can affect quality of life. If symptoms usually only occur in the winter months, it may be seasonal affective disorder (SAD), or major ...

“Unspecified depressive disorder” is used when someone displays depressive symptoms, but there isn’t enough information for a specific diagnosis. Depressive symptoms can be complex and may not clearly ...

The approval of medicines called second-generation antipsychotics has allowed major depressive disorder (MDD) and other conditions linked to it to be treated. A person with MDD is usually prescribed ...

According to the World Health Organization (WHO), about 332 million people around the world live with depression. Milaneschi is the co-lead author of a new study recently presented at the 2025 ECNP ...

Researchers have discovered a surprising change in how cells produce energy in people with depression. Brain and blood cells in young adults with major depressive disorder produced more energy ...

Hyperarousal plays an important role in mental disorders. It influences the severity of insomnia, depression, anxiety, ...