In a two-color experiment (panel a in the figure) DNA from individuals of the same species or different tissue from a single individual (e.g., normal and diseased cells) is extracted and ...

In each type of cell, like a muscle cell or a skin cell, different genes are expressed (turned on) or silenced (turned off). If the cells that are turned on mutate, they could—depending on what role ...

For the cell biologist, identifying changes in gene expression using DNA microarrays is just the start of a long journey from tissue to cell. We discuss how chip users can first filter noise ...

A standard Internet protocol that checks errors made during email transmissions has now inspired a revolutionary method to transform DNA microarray analysis, a common technology used to understand ...

BUFFALO, N.Y. -- A multidisciplinary team of pharmaceutics and computer-science researchers at the University at Buffalo, one of very few teams in the nation applying DNA microarray technology in ...

Comparative genomic hybridization (CGH) was developed to identify pathogenic DNA copy-number changes (e.g., duplications, deletions) on a genome-wide scale, and to map these changes to genomic ...

The human genome project was undertaken to determine the human DNA sequence and analyze variation among individuals. To make use of this information, tools were developed that could collect and ...

The research community's rapid acceptance of microarrays notwithstanding, technical challenges remain. Biochip developers continue to grapple with these issues while upgrading their offerings and ...

Now that gene expression microarray experiments are routine, the challenge is to extract accurate intelligence from the data they produce. The problem isn’t inaccuracies in the analysis software or ...

In the early 1990s, my colleagues and I at Stanford University began tinkering with an interesting weed, the small flowering mustard plant, Arabidopsis thaliana. We set out to study genes involved in ...