Neanderthal, DNA
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The human genome is a rich, complex record of migration, encounters, and inheritance written over thousands of millennia. Genomic research by members of Sarah Tishkoff's lab at the University of Pennsylvania are revisiting a particularly intimate chapter,
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Jumping DNA fragments found to destabilize cancer genome
A study published today in the journal Science reveals how jumping fragments of human DNA, a type of genetic parasite, destabilise the cancer genome. Unstable genomes are a fertile playground for cancer evolution,
A fleeting DNA fold called i‑DNA can switch cancer‑related genes on and off, revealing a hidden structural weak point that future therapies might exploit to collapse tumors.
Human DNA constantly refolds in 3D space, and these looping dynamics regulate gene expression and cell identity.
For decades, scientists believed a fertilized egg’s DNA began as a shapeless mass, only organizing itself once the embryo switched on its genes. But new research reveals that the genome is already carefully arranged in three dimensions long before that critical activation step,
Scientists have identified how specific genetic changes function in cells to influence disease risk and other human health traits. By probing regions of DNA previously linked to disease, the work has created high-resolution maps of DNA variant activity,
For many years, researchers believed that the DNA inside a newly fertilized egg began as a structural ‘blank slate’ – a loose, unorganized mass that would only take shape once the embryo started using its own genes. In this view, order emerged only after the genetic program switched on.
Although there are striking differences between the cells that make up your eyes, kidneys, brain and toes, the DNA blueprint for these cells is essentially the same. Where do those differences come from?
LINE-1 retrotransposons are mobile genome parasites that drive cancer evolution by reshuffling the host genome.
DNA methylation is a highly studied epigenetic modification that regulates genome function and plays key roles in development and disease 1. It is linked to a broad range of conditions, including inflammation, neurological disorders, and cancer. Some ...