Geroscience examines the underlying biology of aging to delay chronic diseases and extend the healthy years of human life.

Scientists have identified prematurely aged astrocytes in the brains of Alzheimer’s patients, particularly those with the APOE4 risk gene. Their findings suggest that cellular senescence in these ...

Neurodegenerative disease profoundly affects structures and pathways responsible for memory, cognition, and higher-order ...

When myelin breaks down, white matter in the brain deteriorates, a change commonly seen with aging. At the same time, microglia, the brain’s primary immune cells, can shift from protective responders ...

Researchers found that the body’s natural recycling system, the lysosome, plays a vital role in removing the protein that drives premature aging. When this system breaks down, aging speeds up. By ...

For decades, scientists have understood that aging begins at the cellular level. But one major question has remained unanswered: how does the aging of individual cells lead to the aging of entire ...

When the four-member crew of Axiom-2 launched into space in May 2023 their 10-day mission was chock full of experiments aimed at understanding human physiology. Results from some of those experiments, ...

Cellular aging, otherwise referred to as cell senescence, occurs when cells remain in a constant and terminal state of growth arrest that prevents their proliferation despite optimal growth conditions ...

As the brain ages, cells in the central nervous system experience metabolic dysfunction and increased oxidative damage. These cellular issues impair the ability to maintain the myelin sheath (the ...